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The activity of GCL, the rate-limiting enzyme for GSH synthesis, was upregulated in neurons co-cultured with GSH-depleted astrocytes, but the neuronal GSH levels were not increased [47]

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Further evidence for the physiological relevance of the GST isomerase activity derives from the coregulation of dehydrogenase and GSTA3 gene transcription in the horse (Loux et al., 2020)